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The outer layer of the skin completely replaces itself every two to four weeks, but when this process is blocked, cancer can grow. A new study from researchers at the University of Pennsylvania has now identified a key regulator of that block known as LSD1, as well as a way to genetically influence the skin to grow in a way that prevents this block from happening. Continue reading “[4 min read] Blocking key regulator could treat non-melanoma skin cancers”
An Australian study has discovered 45 new genetic variants that put people at higher risk of developing basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) – the most common form of skin cancers. Continue reading “[7 min read] 45 new genetic causes of non-melanoma skin cancer identified”
A recent article published in Australian Doctor warned against shave biopsies for pigmented skin lesions suspicious for melanoma. Below, Professor David Wilkinson offers guidance for the best-practice approach to biopsying these lesions in general practice. Continue reading “[4 min read] How to biopsy pigmented skin lesions”
Digitisation has become an indispensable part of medicine, and systems like total body photography and artificial intelligence can now support doctors in some medical fields with the same precision as an expert. For example, new systems are becoming available that aid physicians in the rapid detection of new, altered and malignant moles. Continue reading “[5 min read] Skin cancer diagnosis: Artificial intelligence and full-body photography”
In this month’s skin cancer update, Professor Giuseppe Argenziano looks at an interesting case of trichoblastoma – a rare, cutaneous condition characterised by benign neoplasms of follicular germinative cells – with a real patient example. Continue reading “[3 min watch] Skin Cancer Update with Prof Giuseppe Argenziano [September 2019]”
How does a family history of melanoma affect your patients’ risk of developing melanoma and keratinocyte cancers such as squamous cell carcinoma and basal cell carcinoma? Continue reading “[4 min read] Family history of melanoma increases risk of melanoma, SCC and BCC”
Skin cancer experts warn that Australia is heading for a shortfall in dermatologists – a dangerous situation for the country with the world’s highest rate of melanoma.
With over 800,000 skin cancers diagnosed in Australia each year, it is vital that we have enough doctors with knowledge in skin cancer diagnosis and treatment to meet the rising patient demand. Continue reading “[5 min read] Australia heading for shortfall in skin specialists”
In this webinar, Dr Tony Dicker reviews Picato® and its benefits for the treatment of solar keratosis. Dr Dicker discusses the use of lesion-directed therapies in a clinical setting, including the efficacy and skin reactions of Picato®. Continue reading “[WEBINAR] Benefits and review of Picato for solar keratosis”
In this month’s skin cancer update video, Professor Giuseppe Argenziano discusses how a new therapeutic agent, cemiplimab, might be used in combination with radiotherapy to treat advanced squamous cell carcinoma. Continue reading “[3 min watch] Skin Cancer Update with Prof Giuseppe Argenziano [August 2019]”
A study conducted in 2004 assessed the rate of skin cancer in a cohort of paediatric organ transplant recipients. Five to 16 years post-transplantation, none of the participants had developed skin cancer. Researchers have now re-evaluated the same cohort 10 years later to determine the prevalence of pre-malignant and malignant skin lesions and to identify the known risk factors associated with melanocytic naevi in a paediatric organ transplant population in the UK.
All 98 paediatric organ transplant recipients from the original 2004 study were invited to participate in the longitudinal follow-up study. History of sun exposure, demographics and transplantation details were collected using face‐to‐face interviews, questionnaires and case note reviews. Skin examination was performed for regional count of malignant lesions, benign and atypical naevi.
Of the 98 patients involved in the initial study, eight kidney and 37 liver transplant recipients, with an average follow‐up of 19 years, agreed to participate. Neither skin cancer nor pre-malignant lesions were detected in any of these patients.
Although skin cancer was not observed in the cohort in 2004 or 2014, researchers identified a significant increase in the number of benign naevi, particularly in those reporting frequent sunburn and sunscreen use. When compared with the 2004 cohort, 41 patients in the current cohort had increased numbers of benign naevi, with 11 patients having more than 50 benign naevi. Seventy‐one per cent of benign naevi in the 2014 cohort occurred on sun‐exposed sites (13% head/neck, 35% arms and 23% legs). Patients who regularly used sunscreen had more benign naevi on their arms.
This result is encouraging in not finding an increased risk of skin cancer after a follow-up period of 15–26 years post-transplantation. This may reflect increased sun protection, although in the last 10 years of this 20-year study, patients were using sunbeds, taking sunny holidays and experiencing sunburn more often, despite the earlier sun protection advice. This may reflect that these patients have reached their teenage and early adult years when much advice is ignored. If these high-risk factors continue, then increased skin cancers may be expected if the study continues for another 10 years.
Better ways of providing the sun protection message are needed. As the number of moles correlates with the risk of melanoma, paediatric organ transplant recipients still need regular skin checks and sun protection advice.
Source: Foo, S. , Nightingale, P. , Gazzani, P. , Bader, E. , Ogboli, M. , Martin‐Clavijo, A. , Milford, D. , Kelly, D. , Moss, C. and Thomson, M. (2018), A 10‐year longitudinal follow‐up study of a U.K. paediatric transplant population to assess for skin cancer. Br J Dermatol, 179: 1368-1375. doi:10.1111/bjd.16697
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