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In this webinar, Dr Tony Dicker reviews Picato® and its benefits for the treatment of solar keratosis. Dr Dicker discusses the use of lesion-directed therapies in a clinical setting, including the efficacy and skin reactions of Picato®. Continue reading “[WEBINAR] Benefits and review of Picato for solar keratosis”
In this month’s skin cancer update video, Professor Giuseppe Argenziano discusses how a new therapeutic agent, cemiplimab, might be used in combination with radiotherapy to treat advanced squamous cell carcinoma. Continue reading “[3 min watch] Skin Cancer Update with Prof Giuseppe Argenziano [August 2019]”
A study conducted in 2004 assessed the rate of skin cancer in a cohort of paediatric organ transplant recipients. Five to 16 years post-transplantation, none of the participants had developed skin cancer. Researchers have now re-evaluated the same cohort 10 years later to determine the prevalence of pre-malignant and malignant skin lesions and to identify the known risk factors associated with melanocytic naevi in a paediatric organ transplant population in the UK.
All 98 paediatric organ transplant recipients from the original 2004 study were invited to participate in the longitudinal follow-up study. History of sun exposure, demographics and transplantation details were collected using face‐to‐face interviews, questionnaires and case note reviews. Skin examination was performed for regional count of malignant lesions, benign and atypical naevi.
Of the 98 patients involved in the initial study, eight kidney and 37 liver transplant recipients, with an average follow‐up of 19 years, agreed to participate. Neither skin cancer nor pre-malignant lesions were detected in any of these patients.
Although skin cancer was not observed in the cohort in 2004 or 2014, researchers identified a significant increase in the number of benign naevi, particularly in those reporting frequent sunburn and sunscreen use. When compared with the 2004 cohort, 41 patients in the current cohort had increased numbers of benign naevi, with 11 patients having more than 50 benign naevi. Seventy‐one per cent of benign naevi in the 2014 cohort occurred on sun‐exposed sites (13% head/neck, 35% arms and 23% legs). Patients who regularly used sunscreen had more benign naevi on their arms.
This result is encouraging in not finding an increased risk of skin cancer after a follow-up period of 15–26 years post-transplantation. This may reflect increased sun protection, although in the last 10 years of this 20-year study, patients were using sunbeds, taking sunny holidays and experiencing sunburn more often, despite the earlier sun protection advice. This may reflect that these patients have reached their teenage and early adult years when much advice is ignored. If these high-risk factors continue, then increased skin cancers may be expected if the study continues for another 10 years.
Better ways of providing the sun protection message are needed. As the number of moles correlates with the risk of melanoma, paediatric organ transplant recipients still need regular skin checks and sun protection advice.
Source: Foo, S. , Nightingale, P. , Gazzani, P. , Bader, E. , Ogboli, M. , Martin‐Clavijo, A. , Milford, D. , Kelly, D. , Moss, C. and Thomson, M. (2018), A 10‐year longitudinal follow‐up study of a U.K. paediatric transplant population to assess for skin cancer. Br J Dermatol, 179: 1368-1375. doi:10.1111/bjd.16697
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Hydrochlorothiazide has been associated with an increased risk of squamous cell carcinoma. Recently, a Danish study investigated the association between hydrochlorothiazide use and the risk of Merkel cell carcinoma and malignant adnexal skin tumours. Continue reading “[4 min read] Hydrochlorothiazide use and risk for Merkel cell carcinoma”
In this month’s skin cancer update video, Professor Giuseppe Argenziano continues his discussion from last month about atypical melanocytic lesions: lesions that are histopathologically in between a melanoma and a naevus, with subtle melanoma criteria that are not enough for the pathologist to diagnose the lesion as a melanoma. Continue reading “[9 min watch] Skin Cancer Update with Prof Giuseppe Argenziano [April 2019]”
Are people aware of adequate sun protection measures and do they take appropriate steps to protect themselves from developing skin cancer? An exploratory study looked at the correspondence between knowledge, motivation and sun-protection practices among average people during vacations. Continue reading “[4 min read] Are people aware of sun protection strategies and do they actually use them?”
In this month’s skin cancer update video, Professor Giuseppe Argenziano talks about atypical melanocytic lesions: lesions that are histopathologically in between a melanoma and a naevus, with subtle melanoma criteria that are not enough for the pathologist to diagnose the lesion as a melanoma. Continue reading “[7 min watch] Skin Cancer Update with Prof Giuseppe Argenziano [March 2019]”
This month, we touch on Artificial Intelligence (AI) again, because this is such a fast-moving and fascinating field. Two very well written and short pieces are worth looking at and considering. Continue reading “[3 min read] Artificial Intelligence in clinical practice”
Topical photodynamic therapy is an established treatment option for low‐risk basal cell carcinoma (BCC), but how does its efficacy, cosmesis and tolerability compare with alternative treatments? Continue reading “[5 min read] Photodynamic therapy vs conventional treatments for basal cell carcinoma”
This week we have an engaging case. What do you make of the clinical and dermoscopic images below?
Is there a differential diagnosis? If so, how would you biopsy?