[3 min watch] Skin Cancer Update with Prof Giuseppe Argenziano [May 2019]

skin cancer update

In this month’s skin cancer update video, Professor Giuseppe Argenziano talks about the role of Imiquimod in the treatment of primary melanoma. Using real patient case examples, Giuseppe describes the context in which Imiquimod can be utilised and the type of results physicians can expect. Continue reading “[3 min watch] Skin Cancer Update with Prof Giuseppe Argenziano [May 2019]”

[6 min read] Phenotypic characteristics, pattern of UV exposure, and melanoma risk on different body sites

melanoma

Do phenotypic characteristics and pattern of UV radiation exposure differ according to body site of melanoma? A study investigated the association between phenotypic characteristics, pattern of UV radiation exposure, and risk of melanoma on different body sites. Continue reading “[6 min read] Phenotypic characteristics, pattern of UV exposure, and melanoma risk on different body sites”

[5 min read] Skin cancer rates in paediatric organ transplant recipients

organ transplant

A study conducted in 2004 assessed the rate of skin cancer in a cohort of paediatric organ transplant recipients. Five to 16 years post-transplantation, none of the participants had developed skin cancer. Researchers have now re-evaluated the same cohort 10 years later to determine the prevalence of pre-malignant and malignant skin lesions and to identify the known risk factors associated with melanocytic naevi in a paediatric organ transplant population in the UK.

All 98 paediatric organ transplant recipients from the original 2004 study were invited to participate in the longitudinal follow-up study. History of sun exposure, demographics and transplantation details were collected using face‐to‐face interviews, questionnaires and case note reviews. Skin examination was performed for regional count of malignant lesions, benign and atypical naevi.

Of the 98 patients involved in the initial study, eight kidney and 37 liver transplant recipients, with an average follow‐up of 19 years, agreed to participate. Neither skin cancer nor pre-malignant lesions were detected in any of these patients.

Although skin cancer was not observed in the cohort in 2004 or 2014, researchers identified a significant increase in the number of benign naevi, particularly in those reporting frequent sunburn and sunscreen use. When compared with the 2004 cohort, 41 patients in the current cohort had increased numbers of benign naevi, with 11 patients having more than 50 benign naevi. Seventy‐one per cent of benign naevi in the 2014 cohort occurred on sun‐exposed sites (13% head/neck, 35% arms and 23% legs). Patients who regularly used sunscreen had more benign naevi on their arms.

This result is encouraging in not finding an increased risk of skin cancer after a follow-up period of 15–26 years post-transplantation. This may reflect increased sun protection, although in the last 10 years of this 20-year study, patients were using sunbeds, taking sunny holidays and experiencing sunburn more often, despite the earlier sun protection advice. This may reflect that these patients have reached their teenage and early adult years when much advice is ignored. If these high-risk factors continue, then increased skin cancers may be expected if the study continues for another 10 years.

Better ways of providing the sun protection message are needed. As the number of moles correlates with the risk of melanoma, paediatric organ transplant recipients still need regular skin checks and sun protection advice.

Read more recent research.

Source: Foo, S. , Nightingale, P. , Gazzani, P. , Bader, E. , Ogboli, M. , Martin‐Clavijo, A. , Milford, D. , Kelly, D. , Moss, C. and Thomson, M. (2018), A 10‐year longitudinal follow‐up study of a U.K. paediatric transplant population to assess for skin cancer. Br J Dermatol, 179: 1368-1375. doi:10.1111/bjd.16697

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Case discussion: How would you treat this patient? [22 April]

Case discussion

This week we have an engaging case. A 57-year-old woman who had noticed the depigmented lesion on her arm for some months. Patient thought she may have had a BCC three years before, but was unsure of site and size.

What do you make of the clinical and dermoscopic pictures? How would you biopsy this lesion?

Continue reading “Case discussion: How would you treat this patient? [22 April]”

[9 min watch] Skin Cancer Update with Prof Giuseppe Argenziano [April 2019]

Skin cancer update

In this month’s skin cancer update video, Professor Giuseppe Argenziano continues his discussion from last month about atypical melanocytic lesions: lesions that are histopathologically in between a melanoma and a naevus, with subtle melanoma criteria that are not enough for the pathologist to diagnose the lesion as a melanoma. Continue reading “[9 min watch] Skin Cancer Update with Prof Giuseppe Argenziano [April 2019]”

[3 min read] What to do when a partial biopsy of a suspected melanoma is performed

partial biopsy

This month, we consider what to do when a partial biopsy of a suspected melanoma is performed.

The general advice is that if a punch or shave (partial) biopsy has been done, then an excision biopsy should be done before a formal wide-local excision. This is so that complete staging (of Breslow thickness) can be assured before the excision is done. Continue reading “[3 min read] What to do when a partial biopsy of a suspected melanoma is performed”

Case discussion: How would you treat this patient? [25 March]

Case discussion

This week we have an interesting case. No clinical image or history.

What do you make of the dermoscopic image below? How would you biopsy?

Continue reading “Case discussion: How would you treat this patient? [25 March]”

[4 min read] Are people aware of sun protection strategies and do they actually use them?

sun protection

Are people aware of adequate sun protection measures and do they take appropriate steps to protect themselves from developing skin cancer? An exploratory study looked at the correspondence between knowledge, motivation and sun-protection practices among average people during vacations. Continue reading “[4 min read] Are people aware of sun protection strategies and do they actually use them?”

[7 min watch] Skin Cancer Update with Prof Giuseppe Argenziano [March 2019]

Skin cancer update

In this month’s skin cancer update video, Professor Giuseppe Argenziano talks about atypical melanocytic lesions: lesions that are histopathologically in between a melanoma and a naevus, with subtle melanoma criteria that are not enough for the pathologist to diagnose the lesion as a melanoma. Continue reading “[7 min watch] Skin Cancer Update with Prof Giuseppe Argenziano [March 2019]”

Case discussion: How would you treat this patient? [11 March]

Case discussion

This week we have an interesting case. Here is an adult with a slowly growing pigmented lesion on the nose.

What do you make of the dermoscopic image below? How would you biopsy?

Continue reading “Case discussion: How would you treat this patient? [11 March]”