If you would like to submit a blog post for consideration, please email email@example.com
[3 min read] Dysplastic naevi genetic makeup
This month, I share a useful review article on the often vexed topic of dysplastic naevi. The article summarises new understandings about the genetic makeup of benign and dysplastic naevi, as well as melanoma.
The summary by Ardakani is well worth reading for everyone, and if you want to explore issues around dysplastic naevi more, read the whole article.
In short, what Ardakani shows is that there does seem to be a subset of dysplastic naevi that has a distinct genetic makeup that is different from other dysplastic naevi. However, it is not clear what the genetic changes mean in a biological or clinical way.
So, while our understanding of the detailed biology of naevi continues to grow, we (as GPs) can continue to manage dysplastic naevi as we do now.
That is, any suspicious pigmented skin lesion should be biopsied by excision biopsy (2mm margins). If the pathology report is of mild or moderate dysplasia, no further treatment is needed. If the report is of severe dysplasia, the lesion should be treated as melanoma in situ, and a re-excision with 5mm margins done.
Professor David Wilkinson
Read more from Professor David Wilkinson on recent research:
- What to do when a partial biopsy of a suspected melanoma is performed
- Artificial Intelligence in clinical practice
- Prof David Wilkinson on melanoma guidelines: Dermoscopy
- How will artificial intelligence benefit GPs in skin cancer medicine?
- The problem of dysplastic naevi