[3 min read] Dysplastic naevi genetic makeup

This month, I share a useful review article on the often vexed topic of dysplastic naevi. The article summarises new understandings about the genetic makeup of benign and dysplastic naevi, as well as melanoma.

The summary by Ardakani is well worth reading for everyone, and if you want to explore issues around dysplastic naevi more, read the whole article.

In short, what Ardakani shows is that there does seem to be a subset of dysplastic naevi that has a distinct genetic makeup that is different from other dysplastic naevi. However, it is not clear what the genetic changes mean in a biological or clinical way.

So, while our understanding of the detailed biology of naevi continues to grow, we (as GPs) can continue to manage dysplastic naevi as we do now.

That is, any suspicious pigmented skin lesion should be biopsied by excision biopsy (2mm margins). If the pathology report is of mild or moderate dysplasia, no further treatment is needed. If the report is of severe dysplasia, the lesion should be treated as melanoma in situ, and a re-excision with 5mm margins done.

Professor David Wilkinson


Read more from Professor David Wilkinson on recent research:


Interested in skin cancer medicine?

The HealthCert Professional Diploma programs offer foundation to advanced training in skin cancer medicine, skin cancer surgery or dermoscopy and provide an essential step towards subspecialisation. All programs are university quality-assured, CPD-accredited and count towards multiple Master degree pathways and clinical attachment programs in Australia and overseas. The programs are delivered online and/or face-to-face across most major cities of Australia.

Courses in Skin Cancer Medicine:
Melbourne | Adelaide | Gold Coast | Brisbane | Perth | Sydney | Online

Courses in Skin Cancer Surgery:
Melbourne | Adelaide | Gold Coast | Brisbane | Perth | Sydney

Online courses in Dermoscopy:
Trimester 1: Jan Trimester 2: May | Trimester 3: Sep

Leave a Reply

Your email address will not be published. Required fields are marked *