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Research Review on Melanoma [February]
The February melanoma research review addresses a range of topics including melanoma surveillance, early detection, diagnostic risk factors, and predicting treatment outcomes. The leading article reports surveillance through a specialised clinic as a cost-effective strategy for the management of individuals at high risk of melanoma. Another study assessing patient-performed mobile teledermoscopy for the early detection of melanoma found favourable consumer acceptance.
A paper investigating prognostic impact of lymphovascular invasion in cutaneous melanoma showed lymphovascular invasion has signi cant prognostic impact on nodal involvement, recurrence, and overall survival in cutaneous melanoma. A small study assessing cessation of targeted therapy after a complete response in BRAF-mutant advanced melanoma reports the majority of these patients will relapse. What remains unclear is whether different treatment durations and dosages may be appropriate in these patients providing a more patient-tailored approach.
The concluding papers in this issue include an assessment of a psychoeducational intervention to reduce fear of cancer recurrence. The authors report the intervention was effective in reducing stress and increasing melanoma-related knowledge in people at high risk for another melanoma. A survey of complementary and alternative medicine in melanoma patients found nearly half of the 1089 participants used these medicines and highlighted communication on complementary and alternative medicine should become a regular topic in counselling melanoma patients.
Featured in this issue:
- Cost-effectiveness of skin surveillance through a specialised high risk melanoma clinic
- Clinical features associated with higher risk of melanoma
- Consumer acceptance of patient-performed mobile teledermoscopy
- A gene signature to differentiate melanoma from benign nevi
- Prognostic impact of lymphovascular invasion in cutaneous melanoma
- Factors predictive of outcome after dabrafenib and trametinib treatment
- Cessation of targeted therapy after a complete response in BRAF-mutant advanced melanoma
- 3DCRT vs IMRT after therapeutic groin lymphadenectomy for patients with melanoma
- Outcomes in MBM patients treated with SRS and various systemic immunologic and targeted melanoma agents
- Psychoeducational intervention to reduce fear of cancer recurrence
- Use of complementary and alternative medicine in melanoma patients